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Old Wed Dec 10, 2008, 08:26 AM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Mother with MDS

Hi Francine,
It is true that RCMD is a more mild type than others with more than 5 % blast (immature) cells. Next question is if your mother has any chromosome aberrations and if the answer is yes what chromosome aberrations?

Thalidomid belongs to the first generation immunomodulators – Revlimid (lenalidomid) and Actimid (only in trials) to the second generation. The two last drug have less adverse effect. Revlimid has good effect in about 75 % of the patients with the chromosome aberration 5q deletion and about 25 % of the patients without that aberration.

The researchers can’t decide yet if a patient will respond to Vidaza or if Dacogen will be a better drug for that patient. They are going to start trials to look at that question.
http://www.checkorphan.org/news/esai...stic_syndromes

Up to now Vidaza seem to be the better drug for most patients but we are all different and respond different at drugs.
http://abstracts.hematologylibrary.o...urcetype=HWCIT

Remember to control that your mother gets effective medication to prevent nausea. Best is a combination of Aloxi or similar drugs, dexametasone or similar drugs and Emend.
Kind regards
Birgitta-A
69 yo, dx MDS RCMD May 2006, transfusion dependent from dx, 75 units of packed red blood cells since dx, Desferal without any adverse effects since Aug 2007
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