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Old Sat Aug 13, 2011, 01:39 PM
Hopeful Hopeful is offline
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Join Date: Jan 2009
Location: California, USA
Posts: 766
Hi Marmab,

I like Greg's explanation of the CD4/CD8 ratio. A serious immune attack (like a bad virus or aplastic anemia) can reverse the CD4/CD8 ratio so that you have a lot more killers (CD8) then helpers (CD4). Here is an article that discusses this relative to MDS. It is titled "Dysregulated T Cell Hemeostasis in Bone Marrow Failure":

http://www.aamds.org/sites/default/f...entSummary.pdf

If your CD4 and CD8 cells aren't mentioned in your BMB, I would suspect that they aren't unusual or reversed, but you should discuss this with your doctor (or better yet, a second opinion!)
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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