raising neutrophils
Hi everyone,
I finally, after 15 minutes of seaching old files, found the info from a German study about niacin (also know as B3) raising neutrophils. Bear in mind that my disease, chronic lymphocytic leukemia, a very slow-growing disease, could be way different from yours; I don't know how you will react to it. Best to start slowly. I took a double dose in the AM, ditto the PM; you may want to start with a regular dose. GET THE NO-FLUSH NIACIN, otherwise you may have a reaction.........face flushing, etc.. It has always worked for me, when neuts were low, they then skyrocketed. I take the Solgar brand.
Here's the info:
"A team of researchers at Hannover Medical School in Germany recently
reported a major breakthrough in neutrophil development that may have
important clinical implications. Upon binding to its receptor on the
surface of myeloid progenitor cells, G-CSF turns on an enzyme that
converts intracellular vitamin B3 (nicotinamide) into an activate
metabolite (nicotinamide monocleotide). The researchers found that
this is the rate-limiting step in a signal transduction pathway that
triggers granulopoiesis.
Addition of vitamin B3 or its precursor induced granulocyte
differentiation of cultured hematopoietic stem cells. Administration
of high doses (10-20mg/kg/day) of vitamin B3 to six healthy
individuals resulted in significant increases in neutrophil count over
a 7 day period and a return to physiological cell counts when vitamin
B3 was withdrawn.
These findings identify a new role for vitamin B3 in granulopoiesis
and beg for clinical trials to evaluate the use of vitamin B3 either
alone or in combination with G-CSF for the treatment of neutropenia.
Source:
Skokowa J, Lan D, Thakur BK, et al. NAMPT is essential for the
G-CSF-induced myeloid differentiation via a NAD+-sirtuin-1-dependent
pathway. Nat Med. 2009;15(2):151-158."
This worked great for me, and one other person that I know about. Beware that it's anecdotal at this point and may not help you, but it's not harmful, either. If you try it, let me know your results.
Ellen
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Ellen, age 68; dx. 5/00 with chronic lymphocytic leukemia. Transfusion dependent since 1/11. Now have low platelets of 25, and, very reluctantly will start on Exjade due to SF of 1700. Worried about side effects, because of warnings from Novartis. 
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