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Old Mon Jan 28, 2008, 05:58 PM
Marlene Marlene is offline
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Join Date: Oct 2006
Location: Springfield, VA
Posts: 1,406
New Exjade warning

For anyone on Exjade, please take the time to read the latest update on the drug. They are now saying you should have your liver monitored monthly and they have changed the criteria for when to start chelation. In the past, they said if your FE was >500, you could start Exjade. They have upped that to >1000.

John has been on Exjade for quite a while and his FE finally dropped below 1000. However, his Creatinine is elevated even at a reduced dose. I can't help but think that this is related. His Creatinine was 1.59 on Jan 11 so he stopped the Exjade. He had his creatinine checked again on Jan 25 and it was up to 1.7. This was at 750 mg/day. His Fe went from 992 in Dec to 698 in Jan. Right now he's off the Exjade and is scheduled for a sonogram of his kidneys. Hopefully it's nothing and things will settle down.

http://www.us.exjade.com/hcp/safety/home.jsp

I copied this from the first PDF listed:

UPDATE TO DOSAGE and ADMINISTRATION SECTION:

The decision to remove accumulated iron should be individualized based on anticipated clinical benefit and risks of Exjade therapy. In patients who are in need of iron chelation therapy, it is recommended that therapy with Exjade® (deferasirox) be started when a patient has evidence of chronic iron overload, such as the transfusion of approximately 100 mL/kg of packed red blood cells (approximately 20 units for a 40-kg patient) and a serum ferritin consistently > 1000 mcg/L.

We hope that these updates provide you with the latest information you need regarding EXJADE.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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