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Old Tue Apr 13, 2010, 02:42 PM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Dacogen after Vidaza

Hi King Farouk,
Good with Neulasta!

Here is a report about Dacogen (decitabine) after Vidaza (azacitidine) with an overall response rate of 28%. The drugs work in different ways though both are DNA hypomethylating - decrease methylgroups that silence tumor suppressing genes. I posted a very complicated article about the two drugs a few days ago at "News...".
http://informahealthcare.com/doi/abs...28190701882146

About 25% of patients without the 5q- chromosome aberration respond to Revlimid. I don't think your father's bone marrow can tolerate both Dacogen and Revlimid - both decrease all counts in many patients.
Kind regards
Birgitta-A
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