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Old Sat Aug 20, 2011, 05:29 PM
Greg H Greg H is offline
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Join Date: Sep 2010
Location: North Carolina
Posts: 660
It's the Dysplasia, Silly!

Thanks Dan & Hopeful!

This makes perfect sense:

If, in AA, "Abnormal cells are not found in either the peripheral blood or the bone macro," then the key difference is the abnormal cells -- i.e. the dysplasia that characterizes myelodysplasia.

I think Hopefuls' explanation of how AA could ultimately morph into MDS makes sense to. The folks at NIH who are messed with IST for MDS believe that, if the immune attack on the marrow continues long enough, the build up of cytokines and other stuff start to damage the stem cells and they make abnormal cells.

Great explanations!

Thanks!

Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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