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Hey Ann!
Are you in the NIH trial, some other trial, or doing Danazol outside of a trial? Do you have a TERT or TERC mutation?
I've been doing some reading on the way(s) in which testosterone analogs increase red blood cell production. In the NIH trial, the hope is that the androgen will improve the telomerase cycle, lengthen our telomeres, and thereby improve blood production.
However, I found a study that explained that androgens can also increase the output of EPO from the kidneys, which can stimulate red blood cell production. I'd wager that this effect would be great for folks whose EPO is low, but maybe not as significant for folks (like me) whose kidneys are already screaming for blood.
Good luck with the Danazol!
Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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