OK Paul, we are with you on this one. Naturally it is hard for us to give you accurate thoughts. When I relapsed to AML at about Day +210 my chimerism dropped to 85% after being at 100% from 30 days following transplant. We had a similar choice as you. Firstly have another BMB and then either a DLI or rounds of Vidaza. We decided firstly for the Vidaza and that worked after 3 cycles with each cycle getting better. The unique part of my relapse was that there wasn't any trace of my previously to transplant genetic mutations. It has now been 1 1/4 years since the relapse and I am feeling fine. The doctors stopped my tacrolimus completely when I showed signs of relapse.
We are in this with you so keep us posted and we will help in any way we can.
age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.