[Zoe's Life]

Originally Posted by Birgitta-A

[Here, we report follow-up data on 75 patients. Of these, 66 were started on valproic acid monotherapy, with later addition of all-trans retinoic acid in patients who did not respond or relapsed. Nine patients were treated with valproic acid + all-trans retinoic acid from the start. Median treatment duration was 4 months for valproic acid and 2 months for all-trans retinoic acid.

Hematological improvement, according to international working group criteria for MDS, was observed in 18 patients (24%). Median response duration was 4 months. All-trans retinoic acid exerted no additional effect in patients receiving the combination from the start or benefited primary valproic acid nonresponders.


Birgitta-A

Birgitta,

So median response time is 4 months? Am I understanding this correctly? That isn't very long. Are you a medical professional? You are quite knowlegeable. I am always impressed by what you find.

Zoe