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John couldn't tolerate a full dose of Exjade. His approach was to start at a low dose of 250 mg/day and he worked up to 750 mg/day. He never got to a full dose. He would take a break from the drug for about a week every 3 or 4 weeks and start it up again. His biggest complaint was nausea. He finally reached a point where his kidneys didn't like it so he stopped completely. Fortunately, he was at a point where his HGB was holding at 11 and they would do therapeutic phlebotomies every other month.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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