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A second bone marrow biopsy shouldn't be needed to establish a subtype if she's already had a chromosome analysis. However, patients may be given multiple bone marrow biopsies because previous samples had too few cells, or to evaluate changes in chromosomes over time.
I've read AML that is usually treated with chemotherapy but a different drug is used for subtype M3. The LLS can provide authoritative information about it. But generalizations can get you only so far. Every patient is unique so you'll want to know the confirmed diagnosis and treatment recommendation from your gran's doctors.
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