Hi bgagnon,
Very interesting study!
Vidaza in combination Revlimid with has showed 72% response that is very high - Vidaza as a single drug helps a little more than 50% of the patients.
http://www.ncbi.nlm.nih.gov/pubmed/22915641
Vidaza in combination with Vorinostat showed 30% response but many of these patients had AML and the MDS patients had other severe diseases.
https://ash.confex.com/ash/2011/webp...aper40324.html
Remember that when a patient participates in a trial it is important that he/she is allowed to get the supportive therapy he/she needs for example Neupogen if the WBC are low.
These three drugs are approved but only Vidaza is approved for MDS patients without the chromosome aberration 5qdel. If your dad of some reason can't continue in the study his doctor perhaps can give lower doses of Vidaza in combination with Revlimid or Vorinostat off record.
Hope your dad will have positive effects of his treatment!
Kind regards
Birgitta-A
74 yo, dx MDS 2006, supportive tharapy until 2010. Since then good response to Thalidomide + Prednisone