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Greg,
Where the mismatches are is more important than anything else. My son had a 9/10 match with a completely successful GVH-fre recovery. His mismatch was on the alelle of DQB1. It gets complicated but in general, as a guideline only, DQB1 and DRB1 mismatches may have less serious implications in relation to graft failure or GVH. On the other hand, mismatches on A, B or C may have much more serious implications in relation to graft failure and, more importantly, moderate to severe GVH.
So if you can find out from your doctor where the two mismatches are specifically and discuss the research that is well documented in terms of those two mismatches, you will gain a much clearer picture.
Best wishes,
Nicole
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Nicole, mom to Evan (20); diagnosed SAA November 2007, hATG mid-November 2007, no response after 6 months, unrelated 9/10 BMT June 2008, no GVH, health completely restored thanks to our beloved donor Bryan from Tennessee.
www.caringbridge.org/visit/evanmacneil
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