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The one time Ken forgot not to take it and got a peak reading, his CsA was 728 (as opposed to a trough of 130 a couple of weeks later). That was not immediately following ATG, however. He had already become tx-independant and his dosage had been tweaked down to a much lower maintenance level (200 mg/day) by then than what they'd started him on.
1870 does sound kind of high, but what is Eric's trough level? They seem to like to keep it as high as the patient can tolerate until they see a response. Even after we'd figured out what Ken's "safe for kidneys" dosage was, they raised it again (to 300) for a few months when they did his second ATG. Even though his creatinine was a bit high (1.4) during that time, they only lowered it when he started getting readings of 1.6 and 1.7. By that time he'd already responded to the second round.
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-Lisa, husband Ken age 60 dx SAA 7/04, dx hypo MDS 1/06 w/finding of trisomy 8; 2 ATGs, partial remission, still using cyclosporine
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