Hi All,
Revlimid has been found to interact with another protein that affect its dose levels in the body as well as potential side affects. Revlimid interacts with P-glycoprotein, a molecule that pumps potentially toxic chemicals out of cells and aids in removing them from the body.
The study found that Revlimid levels in patients' blood were often higher than expected, and some patients experienced increased side effects such as electrolyte imbalances and rashes.
Laboratory experiments showed that Revlimid was removed from cells by P-glycoprotein. The rate of removal was reduced when the drug Torisel, which is known to interact with Pgp, was included in the experiments.
http://classic.cnbc.com/id/44064207
Kind regards
Birgitta-A