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Hi, I tested positive homozygous for a MTHFR mutation and I had a high homocysteine level. I took Folic Acid for years and my homocysteine level returned to normal. I participated in a research study re homocysteine and MTHFR back in the early nineties when I worked for a medical laboratory. I was the only one tested who had the mutation (lucky me) and I can't help wondering if its related to my current problem but the doctors have dismissed my theory.
However, and its a big however, recent studies have shown that Folic Acid, while reducing homocysteine, does not reduce the risks associated with the mutation. In fact the studies showed an increased of occurrence of malignancy in people taking Folic Acid supplements. I have not sighted these studies myself, I was told about them by a vascular surgeon and a metabolic medicine specialist.
Having said that, the haematologist I had, insisted I took Folic Acid, B6 tablets and B12 injections and I'm currently on monthly B12 injections ordered by my GP because my B12 level keeps dropping below normal.
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