[rich7]

Hello All,

My previous biopsy from one year ago showed 30-40 percent cellularity, slight dysplasia and 5q deletion. This new biopsy shows no 5q and the following. Any advice or guidance is appreciated!

Adequacy: Limited. Much of the intertrabecular space is empty.

Cellularity: 30% Hypocellular for 41 yrs old.

ERYTHROPOIESIS: Unremarkable
GRANULOPOIESIS: Unremarkable. Increased eosinophils.
MEGAKARYOCYTES: Present
LYMPHOCYTES: Hematogones identified

CLOT SECTION: Fragments of marrow that are 30% cellular with trilinear maturing hematopoiesis. Megakaryocytes are slightly reduced in number. Eosinophils are increased. An iron stain is positive.

Immunophenotyping by flow cytometry (H19-126) shows that a subset of monocytes expresses CD56. Blasts are not increased, and no lymphoma or leukemia is detected.

BONE MARROW:
- SLIGHTLY HYPOCELLULAR MARROW WITH TRILINEAR MATURING HEMATOPOIESIS
- DIAGNOSTIC FEATURES OF A CLONAL MYELOID DISEASE ARE NOT SEEN
- SUBSET OF MONOCYTES POSITIVE FOR CD56 (SEE NOTE)

NOTE: Although this finding is abnormal, it may be seen in some regenerating or reactive marrows. Its clinical significance in this case is uncertain.