Quote:
Originally Posted by evansmom
My son had a 9/10 mismatched BMT and had zero complications as a result. It is, however, VERY important that the doctor discuss with you WHERE the mismatch is located.
For a simplified example, a mismatch on A,B or C can have much more serious potential complications (graft failure, graft vs. host) than a mismatch on DRB1 or DQB1. To complicate matters, it can also make a difference in terms of whether the mismatch is on the alelle or the antigen.
There has been much research on BMT outcomes as a result of specific mismatches and hopefully your doc can explain the potentials as it relates to your situation.
So having said all of this, it is actually possible that the 8/10 donor BMT may carry less potential risk for unfavourable outcome than the 9/10.
Evan's donor was mismatched on the alelle of DQB1 and was A+, while Evan was O+ and just as predicted in studies, Evan's only issue was slightly prolonged engraftment of the red blood cells.
Hope this helps and best wishes,
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I have the difference in the HLA-A.
My HLA-A is 03:01 24:02
Donor HLA-A is 30:01 24:02
What is the antigen and the alelle here???
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Janire, age 31, diagnosed AA september 2007; treated with ATG november 2007, no response; 2xATG april 2008, total remission..... RELAPSE and 3xATG in april 2011....now waiting for a response... not always easy.
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