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Old Tue Mar 6, 2012, 05:28 AM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Vidaza and Dacogen

Hi Ann,
As far as I understand everything Greg wrote is OK. One of the differences between Vidaza and Dacogen seems to be that Vidaza is incorporated into both RNA and DNA. In contrast, Dacogen is incorporated solely into DNA.
http://www.plosone.org/article/info:...l.pone.0009001

Vidaza has showed better overall survival but we know that some patients that don’t respond to Vidaza do respond to Dacogen like the member Kirby Stone.

There are studies reporting that transfusion dependent low risk MDS patients don’t respond well to Vidaza.
http://ash.confex.com/ash/2011/webpr...aper38568.html

One Dacogen study (rather small) showed clinical benefit was shown in 50% of those known to be intermediate-1 MDS.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895778/
Kind regards
Birgitta-A
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