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Ray,
I have been thinking about this question for a couple of days and recall that when I was on higher dose prednisone that i suffered from shortness of breath on heavier exertion, like climbing, that my heart rate was substantially elevated and blood pressure was a little funny. I have not had this problem with Tac and have been on it for over 2 years now. Prednisone also causes your white blood cell count to artificially inflate as it pulls wbcs out of reserve pockets, and it can cause the factory to over rev, creating funky looking neutrophils. I believe that most of that resolves if you reduce or stop the prednisone, assuming no other issues are present.
One thing to really look out for is if you have significantly increased sweating. I picked up PCP (pneumocystis pneumonia) in 2010 while on prednisone and my two symptoms were shortness of breath and extreme sweating in the morning. I did not carry a fever and generally felt better as the day progressed. The symptom that finally got me was that my legs, despite all of the walking and exercise I was doing felt like they were going to give out one day when stepping off of a sidewalk.
We had to do a bronchoscopy to find the pneumonia, because it did not show up on the CT or Xray.
Just a word of caution since you are on so much immune suppression.
dan
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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