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Old Tue Apr 22, 2014, 02:19 PM
ccnarayanan ccnarayanan is offline
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Join Date: Mar 2014
Location: Bangalore, India
Posts: 16
MDS rollercoaster

Now the IPSS score has changed from Int-1 (1) to Int-2 (2). But, considering his age, according to the hemato-oncologist, the medical management option remains the same - that is, Decitabine.

In the last two days, he has been eating better and the doctors and nurses are urging him to sit on a chair during day time. He has had two 20mg (13.33 mg/m^2) infusions of Decitabine per day. Fever is subsiding and he is feeling a little better, but still on anti-emetics, antipyretics (this time, only tablets), and low doses of sedatives. The sedatives are occasionally driving him to some delirious world. The hemato-oncologist feels the fever should probably go away with the third dose of Decitabine. He is still nearly completely immobile. The physiotherapist is providing his services to get him move around.

Now the question - does MDS result in rendering the patient permanently immobile? He has been an ostereoarthritis patient for the last 15-20 years with his weakness around knees, but now he is not even able to lift himself from the bed. He has been moving around well until two weeks ago, but now, someone needs to lift him even to change his position on the hospital bed.
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Father, 83, dx MDS RCUD (RBC) monosomy 7+del7q+del20q Feb 2014, transitioned to RCMD (RBC+platelet) Apr 2014, started Decitabine on 21-Apr-2014 at 2/3rd the recommended dosage on Regimen 2 with no response, terminally ill and transitioned to hospice care on 30-Apr-2014, passed away on 18-May-2014.
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