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Old Tue Nov 11, 2008, 09:11 AM
knstone knstone is offline
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Join Date: Aug 2006
Location: Cincinnati, OH
Posts: 118
Platelets responding to Neumega - moving on to Vidaza

MDS colleagues,
My platelets have responded to a drug rarely used for MDS patients, Neumega.
This was recommended as an option by MDS experts at the Univ of AZ.
This link describes the low dose usage of Neumega for MDS patients:
http://jco.ascopubs.org/cgi/content/abstract/19/21/4165

The article describes use of Neumaga at 10 micrograms/kg of body wt.
In my case at 90 kg the drug is given at 0.9 mg. This dosage is 1/5 the normal use of Nuemega for chemo patients.

My platelets rose from the low 20's to the 40's within 10 days on the low dose Neumega. Side effects are mild edema in ankles and fingers, taking Lasix to control this.

We hope to start Vidaza this week.

I'll start a new entry on Marrowforums when we start the Vidaza.
__________________
Kirby71, RAEB2 dx 2/04, Thalidomide 30 mo, Revlimid 18 mo, No resp Vidaza
6/09 2nd Thalid use, Promacta, Lowdose Dacogen added 10/09 at 40% blasts. 5/11 BMB-blasts 8%.
2/11 2nd Revl restart=good resp, Platelets drop 6/11, 3rd Thalid,+Nplate+Dacogen. 7/12 Cnts stable for 10 mo.
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