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Hi Rschem,
You should compare your current creatinine level to your baseline (ideally pre-ATG). The literature from the drug manufactures along with a number of research papers say that the creatinine rise should be kept below 30% of your baseline to prevent kidney damage.
I don't think you'd want to see your creatinine level get up to 300, as that could be a symptom of kidney failure!
I consulted with a nephrologist and was told to also have my urine checked every 6 months to look for protein - another sign that the kidneys are struggling.
If the signs point to kidney distress, I would discuss with my doctors either lowering cyclosporine dosage or switching to something else.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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