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Transfusions typically take a couple of hours, depending on how much paperwork, cross-checking, etc. they do. You shouldn't need anyone to pick you up afterwards and you should be fine going to work. In fact, you'll probably feel better than when you went in.
After a transfusion you should notice if any symptoms of a problem occur, like shortness of breath, pain, tingling, chills, fever, swelling at the transfusion site, bleeding, and so on. If there's anything out of the ordinary, call the transfusion center or your doctor to report it and ask what to do.
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