[Peter B]

Hi,

I'm 10 months post MUD BMT. After some complications (inc. splenectomy) I'm doing well, the worst symptom now being leg swelling (not all the time but most days I get some). I looked up my meds to see if they're causing it and find that peripheral edema is listed as a side-effect of sirolimus in 58% of patients while tacrolimus is lower at 12-36% (figures from Micromedex). I'm currently on 4mg of siro a day, with no tacro (stopped about 6 weeks ago). I'm reasonably fit and didn't have any edema prior to transplant.

As far as I can see, it is starting to make sense to switch from sirolimus to tacrolimus, especially as siro has a high co-pay.

Has anyone had any experience of doing this switch? Interested to hear also from anyone who has had post-transplant peripheral edema.

Best to all,
Peter