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Old Wed Jul 16, 2008, 05:25 AM
Birgitta-A Birgitta-A is offline
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Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Revlimid/Vidaza/Dacogen

Hi Bev,
You know all MDS patients are different and there are still no methods to know how a patient will respond to the drugs.

Revlimid is best for patients with 5q- (about 75 % respond) - of the other patients about 25 % respond. Patients with low red blood cells, normal white blood cells and normal platelets respond best to Revlimid but as we hardly ever know how the blood tests were when the disease started it´s difficult to know which patients that will respond.

Vidaza (azacitidine) seems to be better than Dacogen (decitabine) for most patients but many patients respond better to Dacogen. Most patients need to be treated at least 4 cycles (each cycle is 28 days) with these drugs.

Then we have the new drugs - histone deacetylase inhibitors - where Zolinza and Epival are approved for other diseases and perhaps can be given off record. MGCD0103 is still only available in clinical trials.

Hope your father will respond to the treatment his doctor choses!
Kind regards
Birgitta-A
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