Quote:
Originally Posted by Birgitta-A
Yes, a low dose of Nplate would probably be OK. Even for patients with Immune Thrombocytopenic Purpura (a bleeding disease) Amgen advices low doses - they should not try to get normal platelet counts.
Kind regards
Birgitta-A
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Hi Birgitta, look, there is a study from the this year ASH. MDS Patients with platelet-counts 0-20 and 30-50 had a lower survival than the patients with 20-30.
2905 Associations Between Platelet Count and Survival and Disease Progression In Thrombocytopenic Patients with Myelodysplastic Syndromes
http://ash.confex.com/ash/2010/webpr...aper27261.html
Perhaps therefore it is not so extremely necessary to try to come to a higher level than 30 by intaking the normal dosis of Romiplostim. If a small dosis leads to 20-30 this could probably be sufficient as compromise: lower platelets-lower intake of Romiplostim- lower rate of side effects/adverse events?
Platelet counts in the range of 20-30 seem quite low compared to "normal" ones.
Do you know if it is possible to assess in advance the individual risk for dangerous bleedings in this range?
(i remember having read something in the direction that the functioning of the platelets can differ considerately..)
Kind regards,
Margarete