Originally Posted by Jacqui
Thanks DanL for your reply.
There have been many opinions from various drs over the years, hopefully this genomics uk project will be able to shed some light on what's going on. It's very scary not knowing what to do next. The unknown is the worst thing. I just thought someone may have been able to clarify why the megakarocytes show low ploidy and the myeloid cells don't go past the myelocyte stage.
Really appreciate you taking time out to reply.
Jacqui - mum to Olivia aged 14
I was going to comment that the low cellularity and low blood counts could be AA like. Some dysplasia in the erythroid line can also be seen with AA.
However, I have never seen reference to "ploidy" in AA BMB results (mine or others on this forum). I have never even heard that term before. Also, it is unusual to me that there is a "reasonable number" of megakaryocytes in the aspirate.
I hope you find some answers. I will keep my eyes/ears open to new research that may reference this.
52 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. Tried slow cyclosporine taper over 4+ years. Platelets fell, so back on cyclosporine. Trisomy 6 clone in 5% of cells.