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Old Tue Apr 5, 2016, 01:28 AM
Hopeful Hopeful is offline
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Join Date: Jan 2009
Location: California, USA
Posts: 766
Hi Emma,

Cyclosporine alone is a reasonable first line of treatment for worsening MAA. It will take a few months for it to work - at least 2-3 months, and possibly more. So this will be a big test of your patience I have read studies where it is successfully used for the treatment of SAA in countries where ATG is not available.

I would get your cyclosporine tested again soon because your initial dosage was so high. It would be good to see that your kidneys are filtering properly now. A good maintenance dose is 5 mg per kg of body weight per day.

Cyclosporine is very hard on the kidneys when you are at high levels. Be sure to drink lots of water, avoid alcohol (and grapefruits), and get to a safe trough level.

Stay positive, and best of luck!
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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