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Old Fri Oct 5, 2012, 10:34 AM
Hopeful Hopeful is offline
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Join Date: Jan 2009
Location: California, USA
Posts: 766
Teo,

Is it true that your mom was only taking 25mg or 50mg of cyclosporine per day? If so, I'm not surprised that it didn't have any affect!

The therapeutic dosage for cyclosporine is 5mg per kg of her body weight per day. So, someone weighing 50 kg (for example) would take 50*5 or 250 mg of cyclosporine per day. This dosage is typically divided between morning and evening to maintain a more stable level in the blood.

If your mom wasn't taking a therepeutic dose, perhaps you could talk to your doctor about giving cyclosporine a real chance.

The cytogenetic report looks at the actual chromosomes in a couple of cells. It counts them and makes sure they look normal. I don't see any results that would indicate that this test was done. If cytogenetics were done, the results would come back in a totally separate report.

Mitosis is the copying of chromosomes when the cells split. Since they didn't see any mitosis in the sample, maybe they couldn't count the chromosomes to do the cytogenetics??? Just a guess...
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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