You are right about the concern about the risk for fibrosis - they have now started the third trial for MDS patients and the second for AA patients.
I suppose Don is in this trial: http://clinicaltrials.gov/ct2/show/N...pag+mds&rank=2
You know when the two new drugs for low platelets were approved I was hoping that they would soon be in trials for MDS because they were in trials for several other diseases with low platelets due to chemo like Hepatitis C. Then I was scared because of the reports about increased fibrosis and blasts after treatment with Nplate. At that time I wrote that platelet transfusions were safer though I know that most patients won't have a good effect after many platelet transfusions. Now I have changed my mind again - perhaps Promacta will be a good drug for MDS patients.
Hope Don will have a positive response!