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Old Tue Dec 13, 2011, 01:37 PM
Hopeful Hopeful is offline
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Join Date: Jan 2009
Location: California, USA
Posts: 766
Hi lacanada1,

I would get that second opinion as soon as you can - before you start any treatments. (I don't consider transfusions treatments though.) Because of your young age, you could be an ideal candidate for IST if you do in fact have AA or low risk MDS without increased blasts or cytogenetic abnormalities.

An immune attack can cause dysplasia if left untreated. Young people with AA or low risk MDS have the best chance of responding to ATG/Cyclosporine. Check your flow cytometry results for a reverse CD4/CD8 ratio (low CD4, high CD8). Some of the more recent research shows this to be a characteristic of an immune system that is out-of-whack and may respond to IST.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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