[PaulS]

Hi Bailie - glad to hear that you've been traveling - two weeks without internet, what a concept!

Yes, recent deaths are very sad. I still miss Tracy.

i had one round of Vidaza along with Veneteclex that I take daily. I'm set for another round in a couple of weeks. It seems likely at this point that a second transplant is inevitable - We don't want to wait until I get weaker or sic, my brother seems healthy enough to be the donor this time - and while the medications may have some impact on the course of the disease, it seems unlikely that it would cause a long term durable remission or cure - that said, nobody's ever tried this before in a relapsing MDS patient so there is perhaps a slight ray of hope. I understand the preliminary data treating patients with just MDS and the drug combination is promising - and maybe I can make some small contribution to medical science.

In the meantime I'm trying to prepare emotionally for another transplant.

The first transplant allowed me to recover sufficiently feel strong again - appreciate life and loved ones in a new and better way - go skiing, finish a renovation project on a beautiful inn in the Adirondacks, take my wife to the beach, attend my son's college graduation feeling strong and filled with pride - hope and love - and best of all, see both my children maturing into amazing young adults. So the transplant one was overall a very positive event - its been the best six months of my life in many ways. Hopefully transplant 2 will go more smoothly and lead to a more durable cure. I'm determined to be an inspiration for those on this board dealing with serious issues and maybe contemplating a transplant of there own - I don't want to end up another sad story! I'll need all the support, thought and prayers from everyone to get there.

Thanks all
p