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This is a great question and I will try to simplify the answer.
Humans have 23 sets of chromosomes for a total of 46. The first 22 pairs are autosomes, and are responsible for passing on the majority of your hereditary genetic traits. The last pair determines your sex and characteristics associated with it. Chromosomes contain DNA, Genes, and proteins that regulate the functions of your body. When you have a 20q deletion, part of the 20th chromosome disappears. Chromosomal abnormalities are very common in MDS. Some are considered to be favorable, some negative. If 20q is found with no other chromosomal abnormalities, it tends to have a milder clinical course than many other abnormalities.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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