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Sorry you have to go through all this. Your Dads been fighting a while.
Its hard to speculate what the doctors are thinking without knowing what tests he's going for. Usually Doctors follow a flow chart. In general if the relapse occurs less than 6 months after the 1st transplant they won't try another transplant and treat it supportively. I read that MM patients have a high incident of secondary hematologic malignancies so I wonder if the MDS was a result of his past treatments for the MM. They can try what Whizbang mentioned and that is to contact the donor get more stem cells and infuse them without any chemo or conditioning before hand to fix the chimerism.
I wish you and your family the best.
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