Sorry it took so long to update on the biopsy results but we FINALLY got them back yesterday. Unfortunately they are not what we were hoping for. Originally we thought it was just a severe HHV6 infection (2 million copies to be exact in the marrow!!) but it also showed an early relapse of the disease. His blast count is 7% at the moment and some of the blast cells have the same clone as when he was first diagnosed. To say we are devastated is an understatement.
He will be going to Duke next week to see about doing a donor lymphocyte infusion from my brother. Dr. M thinks that possibly the virus is the culprit since a severe infection can result in graft failure. The cellcept has been stopped and reduction of the tracrolimus has begun to prevent further relapse and hopefully start some GVL effect. He cant do anything yet until the viral infection is under control which is a 2 week course. He has one week left to go. Has anyone gone through a DLI?
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Daughter of father diagnosed with MDS RAEB-II intermediate risk due to normal cytogenetics. Blasts at 13% peripheral blood at diagnosis with no cytopenias. 6 cycles on Vidaza then on to SCT at Duke. BMT from my brother and now showing signs of relapse. DLI in the works.
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