Hi Margarete,
There are at least 10 studies about Thalidomide in patients with Myelofibrosis and I have found 3 in patients with MDS. The range of the response is wide - 1 to 37 months. Then I read an abstract from ASH 2010 where 8 patients with MF had got Thalidomide or Revlimid with Interferon alfa injections and 2 patients responded more than 5 years.
Since FDA specially has warnings about Nplate in MDS patients due to risk for increased fibrosis and blast cells I think they have to try to show that the drug doesn’t harm these patients - they can get both increased fibrosis and blast cells due to their disease.
In this abstract from ASH 2010 they report about treatment from 6 to 134 weeks:
http://ash.confex.com/ash/2010/webpr...aper33611.html
We have to wait for the article in some journal if we want to know details for example if they did look for increased fibrosis.
Kind regards
Birgitta-A