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Old Thu Jan 6, 2011, 06:07 AM
akita akita is offline
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Join Date: Nov 2010
Posts: 110
Linds for MD Anderson

1. A prognostic score for patients with lower risk myelodysplastic syndrome Prognostic model of lower risk MDS (Only abstract free avaible, but the journal is in the Viennese MedUni-Library and supposedly in some more libraries)

http://www.nature.com/leu/journal/v2.../2405070a.html

2. Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System 2008
Free Fulltext

Here is mentioned a copyright for the MD Anderson Prognostic Risk Model by ..... but i could not yet find the original

http://onlinelibrary.wiley.com/doi/1...ncr.23697/full

3. This year ASH reported a validation of the MD Anderson Prognostic Risk Model

444 Validation of the Newly Proposed MD Anderson Prognostic Risk Model for Patients with Myelodysplastic Syndromes

http://ash.confex.com/ash/2010/webpr...aper29616.html

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I think it helps identifying some persons with IPSS Lower-Risk, who should belong to a higher risk class because of several additional parameters, like age, low platelets etc, that are not indicated in the IPSS. This Risk Model also helps to make a helpful prognosis for some groups of patients who have not been included in validation of original IPSS many years ago, like MDS patients with prior treatments like transfusions. This is important for conducting investigational studies in a more adaequate way. At the time of creation of IPSS most MDS patients were primary MDS and almost not pre-treated. This has changed. Most of the people who undergo studies for new medicaments have already had prior treatments. How to estimate their prognosis? This risk model has been proved to be valide for all MDS-Patient Groups, not only for the prior not treated primary MDs like IPSS was. So it could help of course (so i think) to contribute to a better choice of therapy. When you are classified by IPSS only you could perhaps have Low-risk or Int-1 status, but b< MD Anderson you could have a higher risk-status. So that perhaps another therapy must be chosen to help you.

Kind regards,

Margarete
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Margarete, 54, living in Vienna, Austria,
MDS/AML M2, diagnosed 9/2007, then Chemos, aSZT 4/2008, chronic GVHD
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