My wife had quite a few bone marrow biopsies. For her, local/topical pain relief wasn't enough, so for bone marrow biopsies the hospital started giving her the surgical anesthetic propofol (brand name Deprival), by IV. It worked perfectly to prevent the pain, and recovery was quick and easy. As an added benefit, her hematologist said that they got a better bone marrow sample because her body was relaxed instead of tensed due to the pain. Not all treatment centers take pain issues seriously enough to do this, so you have to speak up about it. Start by asking what pain relief options they have available, and let them know if the answer isn't satisfactory. That's what we did.