Did cyclosporine cause my lymphoma?
I was diagnosed with AA (actually Amegakaryocytic Thrombocytopenia Purpura) in March '06 (age 49) and had ATG in July '06 followed by cyclosporine for almost a year. I was doing ok till June 07 (platelets in the 50s, > WBC and RBC near the bottom of normal range, altho often needing procrit shots for low hemaglobin) - but then this June 07 found enlarged lymph nodes in my groin. This turned out to be diffuse large B cell lymphoma, for which I am now getting chemo (at NYPresbyterian-Cornell,) which is a big challenge given my low counts. The 2nd round of chemo was delayed by 6 days, and the dosage was reduced. In between chemo treatments I have to be supported with whole blood and platelets transfusions.
A few doctors think the lymphoma was caused by the cyclosporine. At least one doctor though thinks the lymphoma was there before the aplastic anemia.
Is there anyone out there who has been through chemo for cancer with aplastic anemia (or any other bone marrow failure disorder?) Any help or insight would be appreciated.
Thanks. I'm so glad to have a forum where I can connect to others who have these rare issues.
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Gail Anne, 52;dx & treated AA '06 (T=ATG/cyclosporine) ; dx non-Hodgkins large B cell lymphoma 7/07 - full remission after R-CHOP chemo at Weill Cornell / moderate AA persists
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