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Hi chrplunk,
Cyclosporine alone is not a typical immune suppressant regimen. When used in combination with the more powerful ATG, it can still take 6-9 months+ to see a response.
A Trisomy 8 mutation is thought to be indicative of an immune attack. So, I would be hesitant to try a hypomethylating agent before one of the other alternatives.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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