My husband also has the ASXL1 mutation along with CBL. We too were told that the ASXL1 is associated with a poorer prognosis, but no one really told us why - is it more resistant to treatment? Less favorable outcome after SCT? That said - he has had a remarkable response to Vidaza (starts his 9th round next month), so much so that his counts are almost all normal now. I like Barb's response - 4 years later and she's still kicking
