Thread: MDS Questions
View Single Post
  #16  
Old Tue Mar 27, 2018, 10:13 AM
Barb Barb is offline
Member
 
Join Date: Jan 2018
Location: Columbus, Ohio
Posts: 28
Rich,
When I was first diagnosed with MDS, I had only the 5q-. They did not do genetic testing them only chromosome testing. I have what's called the TP 53 mutation, which I read is the worst type of AML to have. My current karyotype is complex:
44,XX,del(5)(q13q31),-9,der(17)t(17;21)(q11.2;q11.2),-21,+mar[cp11]/46,sl,+
6,del(8)(q24q24),+9,-mar[5]/88,slx2[cp3]/46,sl,+8,+9[cp1]

The TP53 mutation has to do with chromosome 17 missing the tumor protien 53. I believe the MLL gene is on chromosome 11. I have that one too.

My transplant doctor feels confident she can be successful with a transplant. She is concerned that because of the TP53 the leukemia is likely to return so I'll be on long term
treatment after the transplant. I don't know the details of that yet as I'm just focused on learning to live a life that revolves around chemo and blood counts and preparing for transplant.

I wish you the best. Are you doing the second opinion? Let us know how you are doing.
__________________
Barb. Diagnosed MDS 5q- in 2006. Stable until 2018. Dx high risk AML complex karyotype with TP53 mutation. On Dacogen, moving towards transplant.
Reply With Quote