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Cyclosporine + fluconazole
Hello.
My wife was prescribed with Sandimmune.
4 days ago she was prescribed with Diflucan due to candidosis.
Yesterday she showed high temperature and fatigue. This symptoms were like she had when her cyclosporine concentration was very high. She does not show any symptom of infection.
Cyclosporine and fluconazole are metabolized through cytochrome P450, so combined usage increases concentration of each drug.
How did you managed such cases? What do you think?
Thank you.
All the best to you.
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