Hi Karen,
I can’t find any studies about Vidaza in patients after SCT without relapse. My doctor has written his thesis about Vidaza in MDS.
In the 4th paper (page 43) “Complex effects of azacitidine in primary myelodysplastic and normal bone marrow cell cultures” he reports that they assessed the effect of azacitidine on bone marrow cell growth and colony formation.
“Interestingly, azacitidine in doses up to 5 μM did not affect cell growth or viability in the suspension cultures. Actually, the absolute number of cells per ml was higher in azacitidine treated positions than in controls in 1/10 normal bone marrow and in 4/10 MDS. Neither was there any inhibitory effect on colony formation after exposure to azacitidine in doses up to 0.5 μM for 24 hours. In fact, the number of colonies (especially erythroid colonies) increased by >70% with the lower doses of azacitidine in 5/9 evaluable MDS and 5/13 normal bone marrow.”
http://publications.ki.se/jspui/bits...y%20thesis.pdf
Kind regards
Birgitta-A