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#1
Fri Dec 10, 2010, 08:11 AM
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Neulasta vs Neupogen
Hi all
My Dr mentioned something about Neulasta promoting AML as opposed to Neupogen.....anyone know anything about this? A little unsettling, as he gave me Neulasta twice already, post Vidaza.  This month I am back on Neupogen daily for a week. Dr also mentioned the large hospital that treated me for 2 1/2 months last year won't return his calls...  I think his experience is limited in MDS treatment...but he's the only game in town!As always, any feedback is appreciated!
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Cheri Age 54; dx Oct 2009 AML, induction chemo only;dx MDS July 2010,- PRBC transfusion dependent; Results BMB 8/4/11--- 6-8% blasts; Danazol 100 mg 3xday; quit Exjade/ GI distress; platelets holding 40's; Fluctuation in blasts in blood--Neupogen 3-4xweek; off Revlimid again! Procrit weekly 
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#2
Fri Dec 10, 2010, 09:15 AM
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Neupogen vs Neulasta
Does anyone know of negative effects of Neulasta, re AML/MDS?
My Dr suggested (after 2 rounds already!) that I should be on Neupogen as Neulasta might stimulate leukemia cells..  Any information greatly appreciated..
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Cheri Age 54; dx Oct 2009 AML, induction chemo only;dx MDS July 2010,- PRBC transfusion dependent; Results BMB 8/4/11--- 6-8% blasts; Danazol 100 mg 3xday; quit Exjade/ GI distress; platelets holding 40's; Fluctuation in blasts in blood--Neupogen 3-4xweek; off Revlimid again! Procrit weekly
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#3
Fri Dec 10, 2010, 02:13 PM
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Neupogen vs Neulasta
Hi Cheri,
Now and then I have read about the possibility of increased risk for AML transformation when patients get granulocyt colony stimulating factors like Neupogen or Neulasta. The risk is probably very low and I have not read anything about a difference between the two drugs. http://www.ncbi.nlm.nih.gov/pubmed/20673585 Kind regards Birgitta-A 2 Neupogen injections/week Sept 2007 - June 2010 since then 3 inj/week less than 5 % blast cells
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#4
Fri Dec 10, 2010, 10:26 PM
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thanks!
Birgitta--you are the best! You are like having a second opinion in my back pocket, 24/7!
This forum is lucky to have you! And sorry about the double post--my computer stuttered!
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Cheri Age 54; dx Oct 2009 AML, induction chemo only;dx MDS July 2010,- PRBC transfusion dependent; Results BMB 8/4/11--- 6-8% blasts; Danazol 100 mg 3xday; quit Exjade/ GI distress; platelets holding 40's; Fluctuation in blasts in blood--Neupogen 3-4xweek; off Revlimid again! Procrit weekly
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#5
Sat Dec 11, 2010, 04:43 AM
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Neupogen vs Neulasta
Hi Cheri,
Thank you for the kind words  ! You know it is dangerous to have very low WBCs too since you can get all kinds of infections that will decrease your counts perhaps for a long time. You have probably seen that I think doctors in the US wait too long before they give Neupogen or similar drugs.Kind regards Birgitta-A
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