Chronically low lymphocytes post-ATG?

[KMac]

This is a question related to (but separate from) my recent thread on low WBC.

Prior to ATG for SAA, my lymphocytes were the only cells within normal range (i.e. well over 1000). 7+ months post-ATG, my lymphocytes still have not recovered. They usually run about 350 on my weekly CBC.

My understanding is that lymphocyte counts usually bounce back much faster than this post-ATG. Has anyone else experienced prolonged low lymphocytes post-ATG?

Perhaps it is even related to some other drug I am on, or have been on? I am currently still on cyclosporine, acylclovir, amlodipine, and ambien. Post-ATG (but no longer) I was also on prednizone, voriconazole, levofloxacin, and augmentin.

Thank you,

[dfantle]

My recollection is the cyclosporine helps to keep the lymphocyte #'s low to help your cells recover, because in AA, the lymphocytes have a role in cell destruction. Is this correct though? My memory could be off here...

[Karenish]

This is what I thought also. Lymphocites (sp) are the naughty T cells aren't they?

[Hopeful]

Hi KMac,

I think it is unusual for lymphocytes to stay so low post-horse ATG. It is more commonly seen with rabbit ATG. Looking back at my numbers, my ALC (Absolute Lymphocyte Count) want down to 0 during ATG but came back to normal levels a little over a week after the ATG ended, despite being on high-dose cyclosporine. Later, at about 6 months post-ATG, my doctors played with increasing my cyclosporine dosage again and my ALC decreased slightly, but not as significantly as yours. Platelets were always my nemesis though. Perhaps yours are WBC's. On the positive side, I've also heard and read that slow recoveries are usually more durable then rapid ones. Hope yours continues in that upward direction!

[Lisa V]

Since ATG is designed to target the T-lymphocytes, wouldn't you want them to be low following treatment? I realize there are other lymphocytes besides the T cells, but I'm not sure what the percentage is. Anyone know?

At any rate, our doctors have always focused on the neutrophils and how they're doing. I've never heard any concern expressed about the lymphocytes as long as the ANC remains in an acceptable range.

[Hopeful]

Originally Posted by Lisa V

Since ATG is designed to target the T-lymphocytes, wouldn't you want them to be low following treatment? I realize there are other lymphocytes besides the T cells, but I'm not sure what the percentage is. Anyone know?

Here is a recent article from Blood that talks about this. It says:

"Horse ATG is considered moderately lymphocytotoxic through the action of polyclonal Abs that produce transient lymphodepletion (usually 1-2 weeks duration) and longer elimination of activated T cells, which are assumed to contribute to the induction of tolerance. Rabbit ATG is more efficient at depleting peripheral blood lymphocytes in vivo and is more cytotoxic on a weight basis in vitro."

http://bloodjournal.hematologylibrar...119/2/345.long

[KMac]

Hi everyone,

Thank you for the replies. Especially thank you to Hopeful for pointing out that article.

Yes, from what I have researched also, my low lymphocyte count is unusual 8+ months out. But in the past couple weeks it has risen a bit, from about 350 to about 450. I guess our disease is just very unusual, and we all heal differently and at our own rates.

I have heard the same thing Hopeful about a slow response often being a more resilient one. And indeed as Karenish said, the errant T-cells that cause AA are a type of lymphocytes, so if something in my counts is going to be down, it might as well be them.

My counts continue to improve, my doctor is talking about seeing me much less often, so all in all I consider myself very fortunate.

Kevin

[dfantle]

Are you still taking cyclosporine or a different immune suppressant following your ATG? My recollection is these type of medications also reduce the lymphocytes so the lymphocytes don't continue to destroy your red cells, white cells or platelets... Following ATG. The gradual increase of your lymphocytes may be happening if your team is weaning you off your immunosuppressant medications. Suggest you ask your Dr though at your next visit.

Great to hear your counts are doing so well following your ATG. This is great news.

[marmab]

I have had two horse ATGs, with CSA, and for the first time in 14 months am transfusion free. Looking back at my labs, my lymphocytes have been all over the place, from above normal to below normal (but generally low-normal to below normal), with little apparent rhyme or reason, except of course while undergoing ATG, when the numbers were low. I have also been on varying doses of CSA all this time. The lymphocyte numbers may be tied to the CSA dosage, but I'm not sure (I would have to do some cross referencing to make a correlation). But I, like others, was under the impression that the CSA is supposed to keep the T lymphocytes at bay, thus perhaps resulting in low-ish numbers.

Best regards and stay well!