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#1
Mon Dec 10, 2012, 04:59 AM
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Zolinza (vorinostat) can prevent GVHD
Hi All,
The histone deacetylase inhibitor Zolinza (vorinostat) can prevent GVHD in many patients: https://ash.confex.com/ash/2012/webp...aper47682.html Kind regards Birgitta-A 
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#2
Mon Dec 10, 2012, 12:29 PM
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They call it a "proof of concept first-in-human phase I/II clinical trial" but oral vorinostat certainly made a difference in the trial, with severe acute GVHD reduced from 19% to 4%, less severe aGVHD reduced from 42% to 22%, and mortality reduced from 19% to 13% when comparing the study control group to the vorinostat group.
Despite the small scope of the trial, this is very promising. I wonder if vorinostat would make a difference after the fact for patients with GVHD or if its only target is preventing GVHD.
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