Tacrolimus vs Sirolimus

[Peter B]

Hi,

I'm 10 months post MUD BMT. After some complications (inc. splenectomy) I'm doing well, the worst symptom now being leg swelling (not all the time but most days I get some). I looked up my meds to see if they're causing it and find that peripheral edema is listed as a side-effect of sirolimus in 58% of patients while tacrolimus is lower at 12-36% (figures from Micromedex). I'm currently on 4mg of siro a day, with no tacro (stopped about 6 weeks ago). I'm reasonably fit and didn't have any edema prior to transplant.

As far as I can see, it is starting to make sense to switch from sirolimus to tacrolimus, especially as siro has a high co-pay.

Has anyone had any experience of doing this switch? Interested to hear also from anyone who has had post-transplant peripheral edema.

Best to all,
Peter

[truthlover]

Hi

I am 7 months post-transplant and on tacrolimus 3 mg/day. About six weeks ago my ankles and feet started swelling. My Oncologist doesn't seem concerned but it seems to be getting worse. I am going to discuss it with her on Friday when I see her. Let me know if you find anything that helps.

Michelle