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MDS Myelodysplastic syndromes

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  #1  
Old Thu Nov 5, 2015, 06:23 PM
carrieridge carrieridge is offline
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Cytogenetics Report

Is it clinically relevant if you have the extra chromosome (in my husbands case trisomy 8) in ALL cells analyzed as opposed to having only a percentage of the cells affected? Does it make a difference in prognosis?
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Old Thu Nov 5, 2015, 06:57 PM
Data Data is offline
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My experience

Carrieridge,
I believe it does matter. On my most recent biopsy I had a monosomy 7 in 6 of the 20 cells examined. My doctor said "well you have monosomy 7 but only in 6 of the cells". That would lead me to believe it does matter.

Best of luck

Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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Old Thu Nov 5, 2015, 07:15 PM
Data Data is offline
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Additional info

Carrieridge,
Here is an article on trisomy 8 and references the number of cells with the abnormality.

http://www.mdsbeacon.com/news/2011/0...ith-trisomy-8/



Data
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Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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